Probably the richest, most Hollywood- powerful (young) lesbian on the planet: Megan Elilison. Yes her father is obscenely rich but she is doing interesting things with all that money.
http://www.vanityfair.com/hollywood/...ro-dark-thirty
Also, this year:
"Megan Ellison made history on Thursday, becoming the first woman and only the fourth person to receive two best picture Academy Award nominations in the same year.
The producer earned a trip to the Oscars for her work on “Her” and “American Hustle.” She has previously been nominated for producing 2012′s “Zero Dark Thirty.”