Science and Exploration

[ProfPacker]

My mother took DES:

https://en.wikipedia.org/wiki/Diethylstilbestrol

and I have begun to find studies (as it was given from the 1940's-1971 and beyond off label) because the off spring of the women who were given the drug are now old enough to follow regarding the higher incidence of autoimmune disease, reproductive issues (structural and getting pregnant), mood disorders such as bi polar and depression and finally because of the timing of when it was introduced to the mother (week 8 through the birth) variances in the neurobiology regarding the influx and time of hormones in the brain on gender expression, sexuality and (at this point) in DES sons, more incidences of transitioning.

I am as much interested in the impact of the drug on automimmune diseases and mood disorders as gender expression because my sister and ex (who are one day apart in age) have suffered similar trajectories (mine has been a little different) the were born in 1952 and I was born in 1949 and there might have been different dosing and different strenghts because of the similarities in their reproductive organs being affected, their autoimmune, etc.

Neither of them is as masculinized in id as I am but interestingly, because there have also been studies regarding hormones and handedness, we are all left handed. I am getting more and more into the neurobiology of the brain, etc. as I teach human behavior and development and include more current literatire.

So I was just curious if anyone knows if their mother took DES and if they have an autoimmune diseases. For my sister this has been difficult to correlate and she is very sick with lupus and one large study in Sweden has found a correlation.

Thank you in advance if you should decide to respond

[FireSignFemme]

Originally Posted by ProfPacker

My mother took DES:
I was just curious if anyone knows if their mother took DES and if they have an autoimmune diseases. For my sister this has been difficult to correlate and she is very sick with lupus and one large study in Sweden has found a correlation.
Thank you in advance if you should decide to respond

I was exposed to DES, I don't have Lupus/any other autoimmune disease (as far as I know) nor does anyone else I've known who was exposed to it.

[*Anya*]

Sprawling Maya network discovered under Guatemala jungle

2 February 2018



A split image with one side showing an aerial look on Mayan ruins in Guatemala's northern jungle, and the other side showing a digital landscape that strips away the forest canopy to reveal structures under the ground. WILD BLUE MEDIA/CHANNEL 4

* The Maya city of Tikal was found to be just a fraction of an immense hidden metropolis.
* Researchers have found more than 60,000 hidden Maya ruins in Guatemala in a major archaeological breakthrough.
* Laser technology was used to survey digitally beneath the forest canopy, revealing houses, palaces, elevated highways, and defensive fortifications.

The landscape, near already-known Maya cities, is thought to have been home to millions more people than other research had previously suggested. The researchers mapped over 810 square miles (2,100 sq km) in northern Peten. Archaeologists believe the cutting-edge technology will change the way the world will see the Maya civilisation.

"I think this is one of the greatest advances in over 150 years of Maya archaeology," said Stephen Houston, Professor of Archaeology and Anthropology at Brown University. Mr Houston told the BBC that after decades of work in the archaeological field, he found the magnitude of the recent survey "breathtaking". He added, "I know it sounds hyperbolic but when I saw the [Lidar] imagery, it did bring tears to my eyes."

Most structures are believed to be stone platforms for pole-and-thatch homes. Results from the research using Lidar technology, which is short for "light detection and ranging", suggest that Central America supported an advanced civilisation more akin to sophisticated cultures like ancient Greece or China. "Everything is turned on its head," Ithaca College archaeologist Thomas Garrison told the BBC. He believes the scale and population density has been "grossly underestimated and could in fact be three or four times greater than previously thought".

How does Lidar work?
Described as "magic" by some archaeologists, Lidar unveils archaeological finds almost invisible to the naked eye, especially in the tropics. It is a sophisticated remote sensing technology that uses laser light to densely sample the surface of the earth. Millions of laser pulses every four seconds are beamed at the ground from a plane or helicopter. The wavelengths are measured as they bounce back, which is not unlike how bats use sonar to hunt. The highly accurate measurements are then used to produce a detailed three-dimensional image of the ground surface topography.

Revolutionary treasure map
The group of scholars who worked on this project used Lidar to digitally remove the dense tree canopy to create a 3D map of what is really under the surface of the now-uninhabited Guatemalan rainforest. "Lidar is revolutionising archaeology the way the Hubble Space Telescope revolutionised astronomy," Francisco Estrada-Belli, a Tulane University archaeologist, told National Geographic. "We'll need 100 years to go through all [the data] and really understand what we're seeing."

The Lidar images have surprised surveyors
Archaeologists excavating a Maya site called El Zotz in northern Guatemala, painstakingly mapped the landscape for years. But the Lidar survey revealed kilometres of fortification wall that the team had never noticed before. "Maybe, eventually, we would have gotten to this hilltop where this fortress is, but I was within about 150 feet of it in 2010 and didn't see anything," Mr. Garrison told Live Science.

While Lidar imagery has saved archaeologists years of on-the-ground searching, the BBC was told that it also presents a problem. "The tricky thing about Lidar is that it gives us an image of 3,000 years of Mayan civilisation in the area, compressed," explained Mr Garrison, who is part of a consortium of archaeologists involved in the recent survey. "It's a great problem to have though, because it gives us new challenges as we learn more about the Maya."

Hidden insights
Maya civilisation, at its peak some 1,500 years ago, covered an area about twice the size of medieval England, with an estimated population of around five million. "With this new data it's no longer unreasonable to think that there were 10 to 15 million people there," said Mr Estrada-Belli, "including many living in low-lying, swampy areas that many of us had thought uninhabitable."

Most of the 60,000 newly identified structures are thought to be stone platforms that would have supported the average pole-and-thatch Maya home. The archaeologists were struck by the "incredible defensive features", which included walls, fortresses and moats. They showed that the Maya invested more resources into defending themselves than previously thought, Mr Garrison said.

One of the hidden finds is a seven-storey pyramid so covered in vegetation that it practically melts into the jungle. Another discovery that surprised archaeologists was the complex network of causeways linking all the Maya cities in the area. The raised highways, allowing easy passage even during rainy seasons, were wide enough to suggest they were heavily trafficked and used for trade.

"The idea of seeing a continuous landscape, but understanding everything is connected across many square miles is amazing," said Mr Houston. "We can expect many further surprises," he added.

The Lidar survey was the first part of a three-year project led by a Guatemalan organisation that promotes cultural heritage preservation. It will eventually map more than 5,000 sq miles (14,000 sq km) of Guatemala's lowlands.

http://www.bbc.com/news/world-latin-america-42916261

[*Anya*]

This Mutant Crayfish Clones Itself, and It’s Taking Over Europe

By Carl Zimmer FEB. 5, 2018



The marbled crayfish is a mutant species that clones itself, scientists report. The population is exploding in Europe, but the species appears to have originated only about 25 years ago.

Frank Lyko, a biologist at the German Cancer Research Center, studies the six-inch-long marbled crayfish. Finding specimens is easy: Dr. Lyko can buy the crayfish at pet stores in Germany, or he can head with colleagues to a nearby lake.

Wait till dark, switch on head lamps, and wander into the shallows. The marbled crayfish will emerge from hiding and begin swarming around your ankles.

“It’s extremely impressive,” said Dr. Lyko. “Three of us once caught 150 animals within one hour, just with our hands.”

Over the past five years, Dr. Lyko and his colleagues have sequenced the genomes of marbled crayfish. In a study published on Monday, the researchers demonstrate that the marble crayfish, while common, is one of the most remarkable species known to science.

Before about 25 years ago, the species simply did not exist. A single drastic mutation in a single crayfish produced the marbled crayfish in an instant.

The mutation made it possible for the creature to clone itself, and now it has spread across much of Europe and gained a toehold on other continents. In Madagascar, where it arrived about 2007, it now numbers in the millions and threatens native crayfish.

“We may never have caught the genome of a species so soon after it became a species,” said Zen Faulkes, a biologist at the University of Texas Rio Grande Valley, who was not involved in the new study.

The marbled crayfish became popular among German aquarium hobbyists in the late 1990s. The earliest report of the creature comes from a hobbyist who told Dr. Lyko he bought what were described to him as “Texas crayfish” in 1995.

The hobbyist — whom Dr. Lyko declined to identify — was struck by the large size of the crayfish and its enormous batches of eggs. A single marbled crayfish can produce hundreds of eggs at a time.

Soon the hobbyist was giving away the crayfish to his friends. And not long afterward, so-called marmorkrebs were showing up in pet stores in Germany and beyond.

As marmorkrebs became more popular, owners grew increasingly puzzled. The crayfish seemed to be laying eggs without mating. The progeny were all female, and each one grew up ready to reproduce.

In 2003, scientists confirmed that the marbled crayfish were indeed making clones of themselves. They sequenced small bits of DNA from the animals, which bore a striking similarity to a group of crayfish species called Procambarus, native to North America and Central America.

Ten years later, Dr. Lyko and his colleagues set out to determine the entire genome of the marbled crayfish. By then, it was no longer just an aquarium oddity.

For nearly two decades, marbled crayfish have been multiplying like Tribbles on the legendary “Star Trek” episode. “People would start out with a single animal, and a year later they would have a couple hundred,” said Dr. Lyko.

Many owners apparently drove to nearby lakes and dumped their marmorkrebs. And it turned out that the marbled crayfish didn’t need to be pampered to thrive. Marmorkrebs established growing populations in the wild, sometimes walking hundreds of yards to reach new lakes and streams. Feral populations started turning up in the Czech Republic, Hungary, Croatia and Ukraine in Europe, and later in Japan and Madagascar.

Sequencing the genome of this animal was not easy: No one had sequenced the genome of a crayfish. In fact, no one had ever sequenced any close relative of the crayfish.

Dr. Lyko and his colleagues struggled for years to piece together fragments of DNA into a single map of its genome. Once they succeeded, they sequenced the genomes of 15 other specimens, including marbled crayfish living in German lakes and those belonging to other species.

The rich genetic detail gave the scientists a much clearer look at the freakish origins of the marbled crayfish.

It apparently evolved from a species known as the slough crayfish, Procambarus fallax, which lives only in the tributaries of the Satilla River in Florida and Georgia.

The scientists concluded that the new species got its start when two slough crayfish mated. One of them had a mutation in a sex cell — whether it was an egg or sperm, the scientists can’t tell.

Normal sex cells contain a single copy of each chromosome. But the mutant crayfish sex cell had two.

Somehow the two sex cells fused and produced a female crayfish embryo with three copies of each chromosome instead of the normal two. Somehow, too, the new crayfish didn’t suffer any deformities as a result of all that extra DNA.

It grew and thrived. But instead of reproducing sexually, the first marbled crayfish was able to induce her own eggs to start dividing into embryos. The offspring, all females, inherited identical copies of her three sets of chromosomes. They were clones.

Now that their chromosomes were mismatched with those of slough crayfish, they could no longer produce viable offspring. Male slough crayfish will readily mate with the marbled crayfish, but they never father any of the offspring.

In December, Dr. Lyko and his colleagues officially declared the marbled crayfish to be a species of its own, which they named Procambarus virginalis. The scientists can’t say for sure where the species began. There are no wild populations of marble crayfish in the United States, so it’s conceivable that the new species arose in a German aquarium.

All the marbled crayfish Dr. Lyko’s team studied were almost genetically identical to one another. Yet that single genome has allowed the clones to thrive in all manner of habitats — from abandoned coal fields in Germany to rice paddies in Madagascar.

In their new study, published in the journal Nature Ecology and Evolution, the researchers show that the marbled crayfish has spread across Madagascar at an astonishing pace, across an area the size of Indiana in about a decade.

Thanks to the young age of the species, marbled crayfish could shed light on one of the big mysteries about the animal kingdom: why so many animals have sex.

Only about 1 in 10,000 species comprise cloning females. Many studies suggest that sex-free species are rare because they don’t last long.

In one such study, Abraham E. Tucker of Southern Arkansas University and his colleagues studied 11 asexual species of water fleas, a tiny kind of invertebrate. Their DNA indicates that the species only evolved about 1,250 years ago.

There are a lot of clear advantages to being a clone. Marbled crayfish produce nothing but fertile offspring, allowing their populations to explode. “Asexuality is a fantastic short-term strategy,” said Dr. Tucker.

In the long term, however, there are benefits to sex. Sexually reproducing animals may be better at fighting of diseases, for example.

If a pathogen evolves a way to attack one clone, its strategy will succeed on every clone. Sexually reproducing species mix their genes together into new combinations, increasing their odds of developing a defense.

The marbled crayfish offers scientists a chance to watch this drama play out practically from the beginning. In its first couple decades, it’s doing extremely well. But sooner or later, the marbled crayfish’s fortunes may well turn.

“Maybe they just survive for 100,000 years,” Dr. Lyko speculated. “That would be a long time for me personally, but in evolution it would just be a blip on the radar.”

https://www.nytimes.com/2018/02/05/s...es-europe.html

[cathexis]

Originally Posted by *Anya*

This Mutant Crayfish Clones Itself, and It’s Taking Over Europe

By Carl Zimmer FEB. 5, 2018



The marbled crayfish is a mutant species that clones itself, scientists report. The population is exploding in Europe, but the species appears to have originated only about 25 years ago.

Frank Lyko, a biologist at the German Cancer Research Center, studies the six-inch-long marbled crayfish. Finding specimens is easy: Dr. Lyko can buy the crayfish at pet stores in Germany, or he can head with colleagues to a nearby lake.

Wait till dark, switch on head lamps, and wander into the shallows. The marbled crayfish will emerge from hiding and begin swarming around your ankles.

“It’s extremely impressive,” said Dr. Lyko. “Three of us once caught 150 animals within one hour, just with our hands.”

Over the past five years, Dr. Lyko and his colleagues have sequenced the genomes of marbled crayfish. In a study published on Monday, the researchers demonstrate that the marble crayfish, while common, is one of the most remarkable species known to science.

Before about 25 years ago, the species simply did not exist. A single drastic mutation in a single crayfish produced the marbled crayfish in an instant.

The mutation made it possible for the creature to clone itself, and now it has spread across much of Europe and gained a toehold on other continents. In Madagascar, where it arrived about 2007, it now numbers in the millions and threatens native crayfish.

“We may never have caught the genome of a species so soon after it became a species,” said Zen Faulkes, a biologist at the University of Texas Rio Grande Valley, who was not involved in the new study.

The marbled crayfish became popular among German aquarium hobbyists in the late 1990s. The earliest report of the creature comes from a hobbyist who told Dr. Lyko he bought what were described to him as “Texas crayfish” in 1995.

The hobbyist — whom Dr. Lyko declined to identify — was struck by the large size of the crayfish and its enormous batches of eggs. A single marbled crayfish can produce hundreds of eggs at a time.

Soon the hobbyist was giving away the crayfish to his friends. And not long afterward, so-called marmorkrebs were showing up in pet stores in Germany and beyond.

As marmorkrebs became more popular, owners grew increasingly puzzled. The crayfish seemed to be laying eggs without mating. The progeny were all female, and each one grew up ready to reproduce.

In 2003, scientists confirmed that the marbled crayfish were indeed making clones of themselves. They sequenced small bits of DNA from the animals, which bore a striking similarity to a group of crayfish species called Procambarus, native to North America and Central America.

Ten years later, Dr. Lyko and his colleagues set out to determine the entire genome of the marbled crayfish. By then, it was no longer just an aquarium oddity.

For nearly two decades, marbled crayfish have been multiplying like Tribbles on the legendary “Star Trek” episode. “People would start out with a single animal, and a year later they would have a couple hundred,” said Dr. Lyko.

Many owners apparently drove to nearby lakes and dumped their marmorkrebs. And it turned out that the marbled crayfish didn’t need to be pampered to thrive. Marmorkrebs established growing populations in the wild, sometimes walking hundreds of yards to reach new lakes and streams. Feral populations started turning up in the Czech Republic, Hungary, Croatia and Ukraine in Europe, and later in Japan and Madagascar.

Sequencing the genome of this animal was not easy: No one had sequenced the genome of a crayfish. In fact, no one had ever sequenced any close relative of the crayfish.

Dr. Lyko and his colleagues struggled for years to piece together fragments of DNA into a single map of its genome. Once they succeeded, they sequenced the genomes of 15 other specimens, including marbled crayfish living in German lakes and those belonging to other species.

The rich genetic detail gave the scientists a much clearer look at the freakish origins of the marbled crayfish.

It apparently evolved from a species known as the slough crayfish, Procambarus fallax, which lives only in the tributaries of the Satilla River in Florida and Georgia.

The scientists concluded that the new species got its start when two slough crayfish mated. One of them had a mutation in a sex cell — whether it was an egg or sperm, the scientists can’t tell.

Normal sex cells contain a single copy of each chromosome. But the mutant crayfish sex cell had two.

Somehow the two sex cells fused and produced a female crayfish embryo with three copies of each chromosome instead of the normal two. Somehow, too, the new crayfish didn’t suffer any deformities as a result of all that extra DNA.

It grew and thrived. But instead of reproducing sexually, the first marbled crayfish was able to induce her own eggs to start dividing into embryos. The offspring, all females, inherited identical copies of her three sets of chromosomes. They were clones.

Now that their chromosomes were mismatched with those of slough crayfish, they could no longer produce viable offspring. Male slough crayfish will readily mate with the marbled crayfish, but they never father any of the offspring.

In December, Dr. Lyko and his colleagues officially declared the marbled crayfish to be a species of its own, which they named Procambarus virginalis. The scientists can’t say for sure where the species began. There are no wild populations of marble crayfish in the United States, so it’s conceivable that the new species arose in a German aquarium.

All the marbled crayfish Dr. Lyko’s team studied were almost genetically identical to one another. Yet that single genome has allowed the clones to thrive in all manner of habitats — from abandoned coal fields in Germany to rice paddies in Madagascar.

In their new study, published in the journal Nature Ecology and Evolution, the researchers show that the marbled crayfish has spread across Madagascar at an astonishing pace, across an area the size of Indiana in about a decade.

Thanks to the young age of the species, marbled crayfish could shed light on one of the big mysteries about the animal kingdom: why so many animals have sex.

Only about 1 in 10,000 species comprise cloning females. Many studies suggest that sex-free species are rare because they don’t last long.

In one such study, Abraham E. Tucker of Southern Arkansas University and his colleagues studied 11 asexual species of water fleas, a tiny kind of invertebrate. Their DNA indicates that the species only evolved about 1,250 years ago.

There are a lot of clear advantages to being a clone. Marbled crayfish produce nothing but fertile offspring, allowing their populations to explode. “Asexuality is a fantastic short-term strategy,” said Dr. Tucker.

In the long term, however, there are benefits to sex. Sexually reproducing animals may be better at fighting of diseases, for example.

If a pathogen evolves a way to attack one clone, its strategy will succeed on every clone. Sexually reproducing species mix their genes together into new combinations, increasing their odds of developing a defense.

The marbled crayfish offers scientists a chance to watch this drama play out practically from the beginning. In its first couple decades, it’s doing extremely well. But sooner or later, the marbled crayfish’s fortunes may well turn.

“Maybe they just survive for 100,000 years,” Dr. Lyko speculated. “That would be a long time for me personally, but in evolution it would just be a blip on the radar.”

https://www.nytimes.com/2018/02/05/s...es-europe.html

Wonder if anyone has done research (scientific or kitchen) to see if they are edible by humans.
If we could predate on this exploding mutant species, sounds like they just discovered a very much needed new protein source.